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(19)

(11)

2 650 784

(13)

(51)

IPC

C07K14/765(2006-01-01)

C07K19/00(2006-01-01)

C12P21/02(2006-01-01)

C12N15/81(2006-01-01)

C12N15/62(2006-01-01)

C12N5/10(2006-01-01)

A61K38/38(2006-01-01)

G01N33/563(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2013153816, 2012-05-04

(24)

Start date

2012-05-04

(22)

Actual filing date

2012-05-04

(45)

Published

2018-04-17

(72)

Inventor

Andersen Yan TereDalkhus BernSandli IngerKemeron DzhejsonPlamridzh EndryuFriis Esben PeterDelakhej Karen

(73)

Holder

Albumediks A/S

VERSIONS OF ALBUMIN Russian patent published in 2018 - IPC C07K14/765 C07K19/00 C12P21/02 C12N15/81 C12N15/62 C12N5/10 A61K38/38 G01N33/563 A61P43/00

Abstract RU 2650784 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, namely to obtaining of albumin variants, which can be used in medicine. Polypeptides having at least 90% identity with the original human albumin are obtained, as well as their conjugates, fused proteins, associates, nanoparticles and pharmaceutical compositions.

EFFECT: invention allows to obtain variants of albumin with stronger binding affinity for FcRn and longer half-life in plasma as compared to the original albumin.

51 cl, 24 dwg, 20 tbl, 8 ex

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RU 2 650 784 C2

Authors

Andersen Yan Tere

Dalkhus Bern

Sandli Inger

Kemeron Dzhejson

Plamridzh Endryu

Friis Esben Peter

Delakhej Karen

Dates

2018-04-17—Published

2012-05-04—Filed