FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology, and can be used to optimize the detection of thrombophilia in women with recurrent reproductive losses. Screening is performed to identify thrombophilia in patients with habitual miscarriage. At the same time, 10 markers of the possible presence of thrombophilia are estimated: the loss of two or more pregnancies in an anamnesis; absence of children born alive and/or viable; clinically significant thrombosis in the anamnesis; the presence in the family history of strokes, heart attacks and coronary heart disease in close relatives under the age of 50; presence in the family history of thrombosis and thromboembolism of the pulmonary artery from the next of kin in the age of up to 50 years; pre-eclampsia, eclampsia, HELLP syndrome, severe placental insufficiency, intrauterine growth retardation in the anamnesis; severe complications of the postpartum period in the anamnesis: pleuropneumonia, cardiomyopathy; clinical manifestations indicating the possible presence of thrombophilia from the central nervous system or gastrointestinal manifestations; migraine and venous complications when taking oral contraceptives; Alzheimer's disease in someone from blood relatives. Each of the markers is estimated as 1 point. With a score of 3 or more, the probability of having thrombophilia is more than 40 %.
EFFECT: method allows to isolate a risk group and to improve the diagnosis of congenital and acquired thrombophilia with the habitual loss of pregnancy by evaluating the relevant markers of the possible presence of thrombophilia.
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