NEW 2-STYRYL-DERIVATIVE OF 4-(2,6-DIMETHYL-4-OXO-5-PHENYL-4H-PYRIMIDINE-1-YL)-BENZSULFAMIDE HAVING ENDOTHELIOPROTECTIVE ACTIVITY Russian patent published in 2018 - IPC C07D239/36 A61P7/02 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a new 2-styryl derivative of 4-(2,6-dimethyl-4-oxo-5-phenyl-4H-pyrimidine-1-yl)-benzsulfamide of formula (I) having endothelioprotective activity, and to a method for its preparation. Compound can be used in the manufacture of medicines for cardiology and endocrinology. Compound affects on the induced vasodilation, the rate of platelet aggregation, the level of von Willebrand factor, fibrinogen, endothelial nitric oxide synthase, asymmetric dimethyl arginine, matrix metalloproteinase-1 and protein kinase-C against endothelial dysfunction and exceeds the known drug sulodexide in activity. Compound corresponds to formula .

EFFECT: method for the preparation of a compound of formula (I) is the reaction of 4-(2,6-dimethyl-4-oxo-5-phenyl-4H-pyrimidine-1-yl)-benzsulfamide with salicylic aldehyde in a mixture of ethanol and dimethyl sulfoxide as the reaction medium.

3 cl, 8 tbl, 5 ex