FIELD: chemistry.
SUBSTANCE: invention relates to derivatives of 2-aminofuran, namely to novel biologically active substances – ethyl alcohol (5Z)-2-amino-5-[1-bromo-2-(4-bromophenyl)-2-oxoethylidene]-4-oxo-1H-4,5-dihydrofuran-3-carboxylic acid of the formula I, which can be used as a medicinal antifungal drug. Compound (I) is prepared by reacting (5E)-2-amino-5-[2-(4-bromophenyl)-2-oxoethylidene]-4-oxo-1H-4,5-dihydrofuran-3-carboxylic acid ethyl ester with bromine in the environment of chloroform. This compound is a colorless crystalline substance soluble in dimethylformamide, acetic acid, on heating in ethanol, which is stable during storage. 
EFFECT: preparation of a compound having a pronounced antifungal activity with a minimum inhibitory concentration of 2 mcg/ml for Candida albicans ATCC 10231, 1 mcg/ml for Candida albicans ATCC 885-653.
1 cl, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
| USE OF (5Z)-2-AMINO-5-BROMO-5-(1-BROMO-2-OXO-2-PHENYLETHYLIDENE)-4-OXO-1N-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID NITRILE AS AN AGENT, SHOWING ANTIFUNGAL ACTIVITY |
2021 |
- Ivanov Dmitrij Vladimirovich
- Igidov Nazim Musabekovich
- Novikova Valentina Vasilevna
- Makhmudov Ramiz Ragibovich
|
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2023 |
- Ivanov Dmitrii Vladimirovich
- Igidov Nazim Musabekovich
- Novikova Valentina Vasilevna
|
RU2803601C1 |
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2022 |
- Ivanov Dmitrii Vladimirovich
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- Balandina Svetlana Iurevna
|
RU2799759C1 |
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2021 |
- Shipilovskikh Sergej Aleksandrovich
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- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
- Tkachenko Aleksandr Georgievich
- Nesterova Larisa Yurevna
|
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2022 |
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- Igidov Nazim Musabekovich
- Balandina Svetlana Iurenva
|
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2021 |
- Shipilovskikh Sergej Aleksandrovich
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- Shipilovskikh Darya Aleksandrovna
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|
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2021 |
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|
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2020 |
- Gejn Vladimir Leonidovich
- Bobrovskaya Olga Vasilevna
- Russkikh Aleksandr Alekseevich
- Novikova Valentina Vasilevna
- Makhmudov Ramiz Ragibovich
|
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| ETHYL ETHERS OF 2-AMINO-1-BENZOYLAMINO-4-OXO-5-(2-OXO-2-ARYL-ETHYLIDENE)-4,5-DIHYDRO-1H-PYRROLIDINE-3-CARBOXYLIC ACIDS, HAVING ANTI-TUMOUR ACTIVITY AND METHOD FOR PRODUCTION THEREOF |
2015 |
- Bojchuk Sergej Vasilevich
- Zykova Svetlana Sergeevna
- Galembikova Ajgul Rafikovna
- Ramazanov Bulat Rashitovich
- Igidov Nazim Musabekovich
- Odegova Tatyana Fedorovna
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|
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| APPLICATION OF 1-(4-BROMOPHENYL)-4,4,4-TRICHLOROBUTANE-1,3-DIONE AS AN ANTIFUNGAL ACTIVITY AGAINST ASPERGILLUS FUMIGATUS AND ASPERGILLUS NIGER |
2022 |
- Lisovenko Natalia Iurevna
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|
RU2798469C1 |
