FIELD: pharmacology.
SUBSTANCE: invention relates to the use of biologically active substances of class 2-aminopyrroles, namely, ethyl ether (5E)-2-amino-5-[2-(4-methylphenyl)-2-oxoethylidene]-1-(3-nitrophenyl)-4-oxo-1H-4,5-dihydropyrrol-3-carboxylic acid, general formula
, as analgesics.
EFFECT: compound ethyl ether (5E)-2-amino-5-[2-(4-methylphenyl)-2-oxoethylidene]-1-(3-nitrophenyl)-4-oxo-1H-4,5-dihydropyrrol-3-carboxylic acid has pronounced analgesic activity, as well as low toxicity.
1 cl, 1 tbl
| Title |
Year |
Author |
Number |
| ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Parkhoma Kseniia Iurevna
|
RU2810070C1 |
| SUBSTITUTED ETHYL ESTERS (E)-2-(5-AMINO-4-R1-3-OXO-2-(2-OXO-2-(P-TOLYL)ETHYLIDENE)-2,3-DIHYDRO-1H-PYRROL- 1-YL)-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[b]THIOPHENE-3-CARBOXYLIC ACID, WHICH HAS ANTICANCER ACTIVITY IN THE TREATMENT OF LUNG MELANOMA |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Timin Aleksandr Sergeevich
|
RU2806324C1 |
| 4-(4-BROMOPHENYL)-4-OXO-2-{[3-ETHOXYCARBONYL)-4,5-DIMETHYLTHIEN-2-YL]AMINO}-2-BUTENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY |
2012 |
- Makhmudov Ramiz Ragibovich
- Rubtsov Aleksandr Evgen'Evich
- Shipilovskikh Sergej Aleksandrovich
|
RU2485112C1 |
| 2-(2-(4-NITROBENZOYL)HYDRASONO)-4-OXO-4-(4-METHYLPHENYL)BUTANOIC ACID OCTYL ETHER WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Igidov Nazim Musabekovich
|
RU2798427C1 |
| 4-(4-METHYLPHENYL)-4-OXO-2-[3-(ETHOXYCARBONYL-4,5-R,R-THIOPHEN-2-YLAMINO]BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY |
2008 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragipovich
- Zalesov Vladimir Vasil'Evich
|
RU2389724C1 |
| 1-PHENYLETHYL ETHER OF 2-(2-(4-NITROBENZOYL)HYDRAZONO)-4-OXO-4-(4-METHYLPHENYL)BUTANOIC ACID WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Igidov Nazim Musabekovich
|
RU2798430C1 |
| 4-OXO-N-(FURAN-2-YLMETHYL)-4-(4-CHLOROPHENYL)-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Okoneshnikova Elizaveta Aleksandrovna
|
RU2798425C1 |
| APPLICATION OF AN ANALGESIC AGENT BASED ON POTASSIUM 1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-1-ETHOXY-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-2-YL)AMINO]HEXA-2,4-DIENE-3-OLATE |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776070C1 |
| ETHYL ETHER OF 2-(((Z)-AMINO((Z)-2,4-DIOXO-5-(2-OXO-2-PHENYLETHYLIDENE)PIRROLIDINE-3-YLIDEN)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENCARBOXYLIC ACID WITH ANALGETIC ACTIVITY |
2016 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Vasileva Anastasiya Yurevna
|
RU2631649C1 |
| (Z)-2-[(3-CARBAMOYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMINO]-4-(4-R-PHENYL)-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
|
RU2503671C1 |
