METHOD OF OBTAINING THE PHARMACEUTICAL SUBSTANCE BASED ON IOPROMIDE Russian patent published in 2018 - IPC A61K31/165 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and relates to the process for the preparation of pharmaceutical substance based on iopromide, which includes the following steps: preparation of 1-amino-2,3-dihydroxypropane, preparation of 3-methylamino-1,2-propanediol, preparation of 5-nitroisophthalic acid, preparation of 5-nitroisophthalic acid dimethyl ester, preparation of 5-nitroisophthalic acid monomethyl ester, preparation of the solution of 3-[(2,3-dihydroxypropyl)carbamoyl]-5-nitrobenzoic acid, preparation of the solution of 3-amino-5-[(2,3-dihydroxypropyl)carbamoyl]-benzoic acid, preparation of 3-amino-5-[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodoisophthalic acid, 3-amino-5-{[2,3-bis (acetyloxy)propyl]carbamoyl}-2,4,6-triiodoisophthalic acid, preparation of 3-amino-5-{[2,3-bis(acetyloxy)propyl]carbamoyl-2,4,6-triiodoisophthalic acid chloride, preparation of 5-methoxyacetylamino-2,4,6-dichloride (2,3-diacetoxypropyl)-triiodizophthalic acid, preparation of [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide of 5-methoxyacetylamino-2,4,6-triiodizophthalic acid, preparation of iopromide. Group of inventions also refers to the use of iopromide, which is obtained by this method, as a pharmaceutical substance for the manufacturing of the medicament.

EFFECT: group of inventions ensures the production of high purity iopromide with the high output of the final product.

12 cl, 2 ex