NOVEL METHOD OF PRODUCING IOPROMIDE Russian patent published in 2012 - IPC C07C231/02 C07C235/68 

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel method of producing iopromide, which is used as a contrast substance for X-ray analysis, as well as a novel intermediate compound (20). The disclosed method of producing iopromide of formula (1) involves reaction an acyl chloride of (2,3-diacetoxypropyl)amide5-methoxyacetylamino-2,4,6-triiodoisophthalic acid of formula (19) with 2,3-dihydroxy-N-methylpropylamine in dimethylacetamide solution in the presence of triethylamine to obtain [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide 5-methyoxyacetylamino-2,4,6-triiodoisophthalic acid of formula (20); hydrolysis of the compound of formula (20) in aqueous NaOH solution to obtain the end compound of formula (1). When realising the disclosed method, the dimeric by-product formed during the synthesis process can be removed even without an additional removal procedure, hence highly pure iopromide can be obtained with high output.

EFFECT: design of a novel method of producing iopromide.

11 cl, 4 ex