FIELD: chemistry.
SUBSTANCE: present invention refers to immunology. Antibody and its antigen-binding site capable of binding to a phosphorylated epitope on a human tau protein with high specificity and/or affinity are disclosed. Also disclosed is a pharmaceutical composition, an immunoconjugate, a nucleic acid encoding such an antibody or antigen-binding portion thereof, a host cell and a method for producing an antibody or antigen-binding portion thereof. In addition, the use of an antibody or antigen-binding site thereof for the manufacture of a medicament is described.
EFFECT: present invention can find further application in the treatment of various conditions associated with tau protein, in particular taupathy, Alzheimer's disease and frontotemporal dementias.
47 cl, 15 dwg, 12 tbl
| Title | Year | Author | Number |
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| METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | 2018 |
|
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| ANTIBODIES, SPECIFIC TO HYPERPHOSPHORYLATED TAU-PROTEIN, AND METHODS OF THEIR APPLICATION | 2016 |
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| PHOSPHO-SPECIFIC ANTIBODIES RECOGNIZING TAU | 2012 |
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| PHARMACEUTICAL COMPOSITION | 2011 |
|
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| ANTIBODIES SPECIFIC TO HYPERPHOSPHORYLATED TAU-PROTEIN AND THEIR APPLICATION METHODS | 2017 |
|
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| ANTI-TAU PROTEIN ANTIBODIES AND METHODS OF USING SAID ANTIBODIES | 2016 |
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| USING ANTI-TAU PS422 ANTIBODY FOR TREATING CEREBROPATHIES | 2010 |
|
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| ANTI-LRP6 ANTIBODIES | 2011 |
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| ANTI-BV8 ANTIBODIES AND USING THEM | 2010 |
|
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| ANTIBODIES AGAINST NOTCH2 AND METHODS FOR APPLICATION THEREOF | 2009 |
|
RU2580029C2 |
