PHOSPHO-SPECIFIC ANTIBODIES RECOGNIZING TAU Russian patent published in 2017 - IPC C07K16/18 C12N15/13 C12N5/10 C12N15/63 A61K39/395 A61P25/28 G01N33/53 C07K7/06 

FIELD: medicine.

SUBSTANCE: antibody and its fragment that bind to the phospho-epitope on the Tau protein, as well as the polynucleotides encoding them, are provided; cell lines that produce antibodies; a vector, its host cell and a method for production of the antibody and its functional fragment are proposed. In addition, a pharmaceutical composition, a method for treatment, alleviation or protection against taupathy; a method for induction of a passive immune response in an animal; a method for diagnosis of a protein tau-related disease, disorder or condition, or a predisposition to a protein tau-related disease; a method for monitoring of a minimal residual disease in a patient after treatment with an anti-tau antibody; a method for prediction of patient's response to treatment with an anti-tau antibody; methods for detection of phospho-Tau multimers (pTau) in a brain sample, including postmortem detection; a diagnostic set are proposed.

EFFECT: invention can find further application in the diagnosis and therapy of diseases associated with Tau-protein.

42 cl, 10 dwg, 15 tbl, 11 ex