COMPOSITION AND METHOD FOR PRODUCING A SOLID DOSAGE FORM CONTAINING (Z)-3-(2-OXO-2-(4-TOLYL)ETHYLIDENE)PIPERAZIN-2-ONE Russian patent published in 2018 - IPC A61K31/495 A61K47/38 A61K47/26 A61K47/32 A61K47/12 A61K9/20 A61J3/10 A61P29/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to the field of medicine, the chemical-pharmaceutical industry and pharmacy, specifically to a solid dosage form for oral administration, for the treatment of inflammatory diseases of the musculoskeletal system, and to a method for preparing said dosage form. Dosage form contains a non-steroidal anti-inflammatory drug (Z)-3-(2-oxo-2-(4-tolyl)ethylidene)piperazin-2-one, microcrystalline cellulose, stearic acid and/or a pharmaceutically acceptable salt thereof and a lactose monohydrate in the amounts indicated in the claims. Dosage form may additionally comprise hydroxyethylcellulose and polyvinylpyrrolidone. Solid dosage form is in the form of a coated tablet that allows the preparation of an easily swallowed drug. Tablet of the invention can be obtained by wet granulation and direct compression of the components.

EFFECT: tablet of the invention is characterized by a rapid release of the active substance, sufficient strength, storage-stable, meets the requirements of the pharmacopeia.

11 cl, 3 ex