FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions refers to medicine, chemical-pharmaceutical industry and pharmacy, more specifically to a pharmaceutical composition for oral administration, having hypoglycemic and hypolipidemic activity. Pharmaceutical composition contains (Z)-ethyl 2-(4-(4-chlorophenyl)-2,4-dioxo-3-(3-oxo-3,4-dihydroquinoxalin-2(1H)-ylidene)butanamido)-4-methyl-5-phenylthiophene-3-carboxylate as an active substance and additives –microcrystalline cellulose, sodium croscarmellose, crospovidone, lactose monohydrate, partially pregelatinized corn starch, stearic acid salt. Pharmaceutical composition is presented in the form of a tablet coated with a coating. Second invention relates to a method for preparing a pharmaceutical composition which consists in using wet granulation and direct pressing of various components.
EFFECT: group of inventions is characterized by sufficient mechanical strength, high therapeutic activity, satisfactory technological characteristics and stable during storage for at least 2 years.
12 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PRODUCTION OF (Z)-ETHYL 2-(4-(4-CHLOROPHENYL)-2,4-DIOXO-3-(3-OXO-3,4-DIHYDROQUINOXALINE-2(1H)-YLIDENE)BUTANAMIDO)-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE |
2017 |
- Dmitriev Maksim Viktorovich
- Stepanova Ekaterina Evgenevna
- Chervyakov Artem Valentinovich
- Mashevskaya Irina Vladimirovna
|
RU2644944C1 |
| (Z)-ETHYL2-(4-(4-CHLOROPHENYL)-2,4-DIOXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2(1H)-YLIDENE)BUTANAMIDO)-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE HAVING ANTIDIABETIC ACTIVITY, AND METHOD FOR PRODUCTION THEREOF |
2015 |
- Pchelintseva Darya Igorevna
- Kotegov Viktor Petrovich
- Pavlov Petr Timofeevich
- Mashevskaya Irina Vladimirovna
- Makhmudov Ramiz Ragibovich
|
RU2606230C1 |
| PHARMACEUTICAL ANTIFUNGAL COMPOSITION BASED ON A CHLOROPHENYLBUTANEDIONE DERIVATIVE AND A METHOD FOR PRODUCTION THEREOF |
2019 |
- Mashevskaya Irina Vladimirovna
- Suldin Aleksandr Sergeevich
- Puchnina Svetlana Vladimirovna
|
RU2707286C1 |
| (Z)-4-ARYL-N-[2-(2-HYDROXYMETHYL)PHENYL]-2,4-DIOXO-3-[3-OXO-3,4-DIHYDROQUINOXALINE-2(1N)-YLIDENE]BUTANAMIDES, HAVING ANALGESIC ACTIVITY |
2019 |
- Maslivets Anna Andreevna
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Tretyakov Nikita Alekseevich
|
RU2722178C1 |
| COMPOSITION OF 3-OXY-6-METHYL-2-ETHYLPYRIDINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT IN TABLETTED FORM, METHOD FOR MAKING THEREOF, AND THERAPY |
2007 |
- Kokeladze Merab Revazovich
|
RU2384330C2 |
| D-AMINO ACID OXIDASE INHIBITORS AND THEIR THERAPEUTIC USE |
2018 |
- Tsai, Guochuan Emil
- Wang, Ching-Cheng
- Hsieh, Yuan-Ting
|
RU2795513C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING A BICYCLO-SUBSTITUTED AZO DERIVATIVE OF PYRAZOLONE OR A SALT THEREOF, AND A METHOD FOR PRODUCTION THEREOF |
2017 |
- Lu, Yun
- Chzhan, Sinkhua
- Chzhan, Dajmej
|
RU2733844C2 |
| 1-SULFONYL-1,3-DIHYDROINDOLE-2-ONES, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHOD FOR THEIR PREPARING AND APPLYING |
2003 |
- Ivashchenko A.V.
- Khvat Aleksandr Viktorovich
- Kravchenko D.V.
- Tkachenko S.E.
- Okun' Il'Ja Matusovich
|
RU2259999C2 |
| COMPOSITIONS CONTAINING BENZOPIPERAZINE AS BROMODOMAIN BET INHIBITORS |
2014 |
- Bair Kenneth W.
- Herbertz Torsten
- Kauffman Goss Stryker
- Kayser-Bricker Katherine J.
- Luke George P.
- Martin Matthew W.
- Millan David S.
- Schiller Shawn E. R.
- Talbot Adam C.
- Tebbe Mark J.
|
RU2720237C2 |
| PHARMACEUTICAL COMPOSITION OF MOXIFLOXACIN AND METHOD FOR PRODUCING IT |
2014 |
- Khannanov Timur Shamilovich
- Anisimov Aleksandr Nikolaevich
- Bjakrova Ramzija Akramovna
- Gazizova Nailja Ganievna
- Kavieva Alija Ravilevna
|
RU2558932C1 |
