METHOD FOR PREDICTING THE FREQUENCY OF EXACERBATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Russian patent published in 2018 - IPC G01N33/48 G01N33/50 A61B5/00 A61B10/00 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine and is a method for predicting the frequency of exacerbations in chronic obstructive pulmonary disease (COPD). Use the results of the test with an estimate of the distance traveled by the patient in 6 minutes, assess the impact scales, symptoms and activity, calculate the number of cigarettes smoked per year, determine the fact of smoking at the time of examination, perform an oropharyngeal smear from the posterior pharyngeal wall with DNA isolation and determine the number of operational taxonomic units of the family by sequencing the V3–V4 portions of the bacterial 16S rRNA gene Propionibacteriaceae, family Acidaminobacteraceae, genus Bradyrhizobium, genus Treponema, genus Ruminococcus, species Rothia mucilaginosa, species Brevundimonas diminuta, species Pseudomonas viridiflava, species Acinetobacter schindleri, genus Sphingopyxis alaskensis. At Y less than 38 scores, predict no more than one exacerbation per year, not requiring hospitalization. At Y equal to 38 scores and above, predict two or more exacerbations per year. Invention provides an increase in the accuracy, informativity and sensitivity of the forecasting method.

EFFECT: data obtained are quantitative variables in the logistic regression equation for calculating Y scores.

1 cl, 1 dwg, 1 ex, 3 tbl