FIELD: medicine; pharmaceuticals.
SUBSTANCE: present document describes a pharmaceutical composition adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods of their use in the treatment of bacterial, protozoal, and other infections. Pharmaceutical composition comprises one or more said antibiotic compounds, lactic acid or pharmaceutically acceptable salt thereof, amino acid that have side chain functional groups that are ionizable under physiological conditions, and pharmaceutically acceptable salts thereof, and combinations thereof. Antibiotic compound is preferably solithromycin. Said amino acid is histidine, aspartic acid, glutamic acid, or combinations thereof. Kit and a method for treating a patient having a bacterial infection, the use of said composition in the treatment of bacterial infection are also described.
EFFECT: invention prevents undesirable deposition of drugs during or immediately after administration.
29 cl, 8 dwg
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