FIELD: chemistry.
SUBSTANCE: invention relates to novel polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4 carboxylic acid.
EFFECT: technical result: obtaining novel polymorphic forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4 carboxylic acid, which are stable and non-hygroscopic, which can be used to prepare a medicament for treating conditions mediated by 5-HT4 activity.
16 cl, 3 tbl, 11 ex, 14 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMORPH FORM OF 4-{[4-({[4-(2,2,2-TRIFLUOROETHOXY)-1,2-BENZISOXAZOL-3-YL]OXY}METHYL)PIPERIDIN-1-YL]METHYL}-TETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID | 2012 |
|
RU2616978C2 |
| BENZISOXAZOLE SALT DERIVATIVE | 2015 |
|
RU2679619C2 |
| 5-HT4 RECEPTOR AGONIST AS PROKINETIC AGENT | 2012 |
|
RU2597766C2 |
| 5-HT4-RECEPTOR AGONIST FOR GASTROPARESIS | 2015 |
|
RU2708686C2 |
| GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2664533C2 |
| N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2669922C2 |
| PYRAZOLE QUINOLINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION | 2012 |
|
RU2621037C2 |
| AMIDES OF CONDENSED PIPERIDINE AS MODULATORS OF ION CHANNELS | 2014 |
|
RU2741810C2 |
| AMINOTETRAHYDROPYRANES AS DIPEPTIDYLPEPTIDASE-IV INHIBITORS FOR TREATING OR PREVENTING DIABETES | 2010 |
|
RU2550508C2 |
| CRYSTALLINE FORMS OF DIAZABICLOCTANE DERIVATIVE AND A METHOD OF THEIR PRODUCTION | 2014 |
|
RU2801220C2 |
