5-HT4 RECEPTOR AGONIST AS PROKINETIC AGENT Russian patent published in 2016 - IPC A61K31/454 C07D413/12 C07D413/14 A61P1/00 

FIELD: veterinary science.

SUBSTANCE: disclosed group of inventions is intended for stimulating antral (upper portions) and colonic (lower portions) motility of an animal suffering from gastrointestinal diseases. Disclosed is use of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]-oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid or a pharmaceutically acceptable salt thereof for preparing a medicinal agent for stimulating antral (upper portions) and colonic (lower portions) motility of an animal, including a mammal suffering from gastrointestinal diseases. Disclosed is a pharmaceutical composition for stimulating antral (upper portions) and colonic (lower portions) motility of an animal, including a mammal suffering from gastrointestinal diseases, which contains a therapeutically effective amount of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]-oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid or a pharmaceutically acceptable salt thereof. Disclosed is a method for stimulating antral (upper portions) and colonic (lower portions) motility of an animal, including a mammal suffering from gastrointestinal diseases, which comprises administering to an animal, including a mammal, 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]-oxy}methyl)piperidin-1-yl]methyl}tetrahydro-2H-pyran-4-carboxylic acid or a pharmaceutically acceptable salt thereof.

EFFECT: use of disclosed group of inventions is highly effective for stimulating antral (upper portions) and colonic (lower portions) motility of an animal, including a mammal suffering from gastrointestinal diseases.

12 cl, 5 dwg, 1 ex