PROTEIN-PEPTIDE COMPLEX INCREASING THE VIABILITY OF FOLLICULES IN MAMMAL OVARIANS Russian patent published in 2018 - IPC A61K35/12 A61K35/54 A61K38/38 A61P15/08 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular reproductive biology, and can find application in medicine, pharmacology and veterinary medicine. Protein-peptide complex is obtained from the ovarian tissue of cows by extraction in water-salt solution at a temperature of + 4–5 °C, separation from the extract after treatment with ammonium sulfate by reversed-phase HPLC using a high pressure chromatograph. Complex contains peptides with molecular weights of 1,000–8,000 Da and a protein, bovine serum albumin gi | 1351907 with a molecular weight of 66,690 Da, at mass ratio peptides:protein (1):(1–5).

EFFECT: proposed protein-peptide complex provides an increase in the viability of follicles in the ovaries of mammals at a concentration of total protein 10^-9 mg/ml, it does not have allergenic, mutagenic and sensitizing properties and does not show toxicity.

1 cl, 2 dwg, 4 tbl, 13 ex