PROTEIN-PEPTIDE COMPLEX HAVING A PROTECTIVE ACTION ON THE STATE OF TISSUES OF THE POSTERIOR EYE - SCLERAL SHELL, RETINA, PIGMENT EPITHELIUM, CHOROID Russian patent published in 2019 - IPC A61K35/30 A61K38/17 A61K38/38 A61P27/02 A61F9/00 A61P43/00 

Abstract RU 2701566 C1

FIELD: medicine.

SUBSTANCE: invention refers to biotechnology and medicine. Disclosed is a pharmacological composition having a protective action on the state of tissues of the posterior eye – scleral shell, retina, pigment epithelium, choroid, which is an aqueous solution in concentration 10-7–10-17 mg/ml and consisting of a chaperone-like activity protein-peptide complex containing peptides with molecular weight from 1,000 to 6,000 Da and protein with molecular weight 66,000–68,000 Da, related to a family of blood serum albumins, as well as lipids and carbohydrates, obtained by separating from the scleral shell of the eye of vertebrate animals IEF-fractions separated and collected by isoelectric focusing (IEF) in the pH range <3.0, mixed in equimolecular ratios and obtained as a result of successive extraction of the scleral shell of the eyes of vertebrates, fractionation and separation of obtained fractions using reverse-phase high-performance liquid chromatography (HPLC).

EFFECT: invention ensures adhesion of intercellular interactions in the eye tissue, integrity of collagen fibers and increased viability of fibroblasts, as well as maintenance of adhesion between tissues of the posterior eye, increased viability of cells, preservation of the status of cell adhesion, proliferation and differentiation; invention enables to obtain a highly purified preparation for preventing and treating eye diseases associated with said disorders.

1 cl, 2 dwg, 4 tbl, 19 ex

Similar patents RU2701566C1

Title Year Author Number
PROTEIN-PEPTIDE COMPLEX AND DRUG PREPARATION AGENT, WHICH IS PROTEIN-PEPTIDE COMPLEX 2018
  • Ilina Anna Pavlovna
  • Krasnov Mikhail Sergeevich
  • Iamskova Viktoriia Petrovna
  • Iamskov Igor Aleksandrovich
RU2716819C1
PHARMACOLOGICAL SUBSTANCE OF MEMBRANOTROPIC HOMEOSTATIC TISSUE-SPECIFIC BIOREGULATORS ISOLATED FROM VARIOUS TISSUES AND BIOLOGICAL FLUIDS OF ANIMALS 2021
  • Yamskova Viktoriya Petrovna
  • Ilina Anna Pavlovna
RU2797514C1
KIT OF A PHARMACOLOGICAL AGENT INTENDED FOR IMPROVING THE BLOOD FLOW IN THE CEREBRAL CORTEX AND RESTORING MOTOR AND COGNITIVE FUNCTIONS OF THE BODY 2021
  • Yamskova Viktoriya Petrovna
  • Ilina Anna Pavlovna
RU2787479C1
SUBSTANCE FOR PRODUCING AN AGENT WHICH INCREASES VIABILITY AND MOTILITY OF SPERMATOZOA IN MAMMALS 2018
  • Elistratov Pavel Alekseevich
  • Ilina Anna Pavlovna
  • Evdokimov Valerij Vasilevich
  • Turovetskij Valerij Borisovich
  • Yamskova Viktoriya Petrovna
  • Yamskov Igor Aleksandrovich
RU2725491C2
BIOLOGICALLY ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION IN THE FORM OF STERILE AQUEOUS DISPERSION FOR CONJUNCTIVAL IN THE FORM OF DROPS AND SUBJUNCTIVAL, PARA -, RETROBULBAR INJECTION ADMINISTRATION IN THE CONDUCTED THERAPIES OF VASCULAR AND DYSMETABOLIC OPHTHALMOLOGICAL DISEASES 2021
  • Nazarenko Anna Borisovna
  • Sokolov Mikhail Anatolevich
RU2771678C1
PROTEIN-PEPTIDE COMPLEX INCREASING THE VIABILITY OF FOLLICULES IN MAMMAL OVARIANS 2017
  • Elistratov Pavel Alekseevich
  • Krasnov Mikhail Sergeevich
  • Ilina Anna Pavlovna
  • Yamskova Viktoriya Petrovna
  • Yamskov Igor Aleksandrovich
RU2660587C1
METHOD FOR PREPARING MEDICINAL AGENT FOR TREATMENT OF MYOPIA AND EYE SCLERAL ENVELOPE DISEASES AND VITREORETONOPATHY 2005
  • Jamskov Igor' Aleksandrovich
  • Jamskova Viktorija Petrovna
  • Nagovitsyn Anatolij Vasil'Evich
  • Krasnov Mikhail Sergeevich
RU2315606C2
PROTEIN-PEPTIDE AGENT WITH A TISSUE STRUCTURE-RESTORING EFFECT USED AS A SUBSTANCE FOR PHARMACEUTICAL AND FOOD PRODUCTS 2022
  • Krasnov Mikhail Sergeevich
RU2799330C1
METHOD FOR PREPARING MEDICINAL AGENT FOR TREATMENT OF EYE RETINA AND PIGMENT EPITHELIUM AND EYE VASCULAR ENVELOPE 2005
  • Jamskov Igor' Aleksandrovich
  • Jamskova Viktorija Petrovna
  • Nagovitsyn Anatolij Vasil'Evich
  • Krasnov Mikhail Sergeevich
RU2311915C2
METHOD FOR PREPARING MEDICINAL AGENT FOR TREATMENT OF EYE RETINA DISEASES 2005
  • Jamskov Igor' Aleksandrovich
  • Jamskova Viktorija Petrovna
  • Nagovitsyn Anatolij Vasil'Evich
  • Krasnov Mikhail Sergeevich
RU2311914C2

RU 2 701 566 C1

Authors

Sidorskij Egor Vladimirovich

Ilina Anna Pavlovna

Krasnov Mikhail Sergeevich

Yamskov Igor Aleksandrovich

Yamskova Viktoriya Petrovna

Dates

2019-09-30Published

2018-05-29Filed