FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to a tablet for the treatment of diseases and disorders associated with abnormal levels of serotonin. Pharmaceutical composition in the form of a tablet is obtained from intragranular and extragranular components, where the intragranular components consist of hippurate (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate, anhydrous lactose, hydroxypropylcellulose, croscarmellose sodium, magnesium stearate and extragranular components consist of anhydrous lactose, croscarmellose sodium, colloidal silicon dioxide and magnesium stearate.
EFFECT: invention makes it possible to obtain a solid dosage form in the form of a tablet that has a hardness and stability.
16 cl, 3 dwg, 14 tbl, 11 ex
Title |
Year |
Author |
Number |
CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDINE-2-YL)AZETIDINE-1-YL]METHANONE |
2016 |
|
RU2762181C2 |
PHARMACEUTICAL COMPOSITION CONTAINING N-[3-CHLOR-4-[(3-FLUOROPHENYL)METHOXY]PHENYL]-6-[5[[[2-(METHYLSULPHONYL)ETHYL]AMINO]METHYL]-2-FURYL]-4-QUINAZOLINAMINE |
2009 |
- Katrin Rimkus
- Frank Muskulus
- Zandra Brjuk
- Jana Pehtts
|
RU2548757C2 |
SOLID PHARMACEUTICAL COMPOSITION CONTAINING 1-(3-(2-(1-BENZOTHIOPHENE-5-YL)ETOXY)PROPYL)AZETIDINE-3-OL OR ITS SALT |
2013 |
- Inaba Khiroyuki
- Nagata Mitsukhiro
|
RU2625767C2 |
CRYSTALLINE FORMS OF (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE |
2013 |
|
RU2652377C2 |
(S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDINE-1(2N)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS |
2015 |
- Feng, Tao
- Zhang, Dan
- Marinaro, William Anthony, Jr.
- Lee, Alfred
- Lee, Yung-Chi
- Bahl, Deepak
|
RU2712148C2 |
PILL CONTAINING 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)ETHOXY)PROPYL)AZETIDIN-3-OL OR ITS SALTS |
2016 |
- Kano Atsusi
- Inaba Khiroyuki
- Oura Taj
|
RU2733404C2 |
SALTS OF 4-((2-(6-(4-METHYLPIPERAZINE-1-CARBONYL)-NAPHTHALEN-2-YL)ETHYL) AMINO)QUINAZOLINE-6-CARBONITRILE AND PHARMACEUTICAL COMPOSITION |
2017 |
- Aleshunin Pavel Aleksandrovich
- Evstigneeva Elena Vladimirovna
- Kopylova Olga Viktorovna
|
RU2641001C1 |
TABLET COMPOSITION COMPRISING CINACALCET HYDROCHLORIDE |
2013 |
- Murpani Dipak
- Vivankos Martines Marta
|
RU2662562C2 |
PHARMACEUTICAL COMPOSITIONS BASED ON N-CARBAMOYL-METHYL-4-PHENYL-2-PYRROLIDONE |
2012 |
- Fazylov Marat Feliksovich
|
RU2560691C2 |
SOLID DOSAGE FORMS OF PALLBOCYCLOB |
2016 |
- Ibrahim Fady Makram Louiz
- Mullarney Matthew Patrick
- Shanker Ravi Mysore
- Spong Barbara Rodriguez
- Wang Jian
|
RU2686840C1 |