GUANIDINOBENZOIC ACID ESTER COMPOUND Russian patent published in 2018 - IPC C07C279/18 C07D217/26 C07D307/81 C07D333/24 C07D333/40 C07D333/68 C07D333/70 A61K31/24 A61K31/343 A61K31/381 A61K31/472 A61P13/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, that can be used to prevent or treat kidney diseases. In formula (I), L¹ is a bond or C_1-6alkylene, L² is C_1-6alkylene which may be substituted with a substituent selected from group D1, R¹ is H, C_1-6alkyl which may be substituted with a substituent selected from the group consisting of phenyl, which may be substituted with a substituent selected from group D2, an aromatic heterocyclic group which may be substituted with a substituent selected from group D2, and -CO₂H, or R¹ is combined with the nitrogen atom to which it is bonded and the HO₂C-L² group on the nitrogen atom to form a cyclic amino group which may be substituted with -CO₂H. D1 is -CO₂H, phenyl substituted with -CO₂H, or C_1-6alkyl substituted with -CO₂H, D2 is -CO₂H or C_1-6alkyl substituted with -CO₂H, the aromatic heterocyclic group is an aromatic monocyclic heterocyclic group having from 5 to 6 ring units, which contains at least one heteroatom selected from S, or an aromatic bicyclic heterocyclic group formed by condensing an aromatic monocyclic heterocycle with a benzene ring, and ring B is naphthalenediyl, 1,2,3,4-tetrahydronaphthalenediyl, 2,3-dihydroindenediyl, benzothiophenediyl, benzofuranediyl or 2,3-dihydrobenzofurandiyl.

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EFFECT: invention also relates to a pharmaceutical composition comprising said compounds, the use of the compound or pharmaceutical composition for preventing or treating kidney diseases and a method for preventing or treating kidney diseases.

27 cl, 51 tbl, 9 ex