NOVEL PYRIDINE DERIVATIVE AND DERIVATIVE OF PYRIMIDINE (3) Russian patent published in 2009 - IPC C07D213/75 C07D239/47 A61K31/4409 A61K31/496 A61K31/506 A61K31/5377 A61P35/00 A61P35/04 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula (I) , where R¹ represents 3-10-member non-aromatic heterocyclic group, where group is limited by group containing nitrogen as ring-constituting atom, and nitrogen, having additional bond, or group represented by formula -NR^11aR^11b, where R^11a and R^11b can be similar or differ from each other, and each represents hydrogen, C_1-6 alkyl, C_3-10 cycloalkyl, C_6-10 aryl, 5-10-member heteroaryl or 4-10-member non-aromatic heterocyclic group, and R^11a and R^11b can be substituted with substituent selected from group of substituents A or group of substituents B, and R¹ can be substituted with substituent selected from group of substituents A or group of substituents B; R² and R³ represent hydrogen; R⁴, R⁵, R⁶ and R⁷ can be similar or differ from each other, and each represents hydrogen, halogen, C_1-6 alkyl; R⁸ represents hydrogen or C_1-6 alkyl; R⁹ represents 3-10-member non-aromatic heterocyclic group, where group is limited by group containing nitrogen as ring-constituting atom, and nitrogen, having additional bond, or group represented by formula -NR^11aR^11b, where R^11a and R^11b have the same values as described above; n represents integer 1 or 2; and X represents group, represented by formula -C(R¹⁰)=, or nitrogen, where R¹⁰ represents hydrogen; where group of substituents A consists of halogen, hydroxyl and oxogroup; where group of constituents B consists of C_1-6 alkyl, C_3-10 cycloalkyl, C_6-10 aryl, 5-10-member heteroaryl, 3-10-member non-aromatic heterocyclic group, C_1-6 alkoxy, 5-10-member heteroaryloxy, 4-10-member non-aromatic heterocyclic oxygroup and group represented by formula -T¹-T²-T³, and each group in group of substitutes B can be substituted with substituent selected from group of substituents C, where T¹ represents direct bond or C_1-6 alkylene, T² represents group represented by formula -NR^T1-, T³ represents hydrogen or C_1-6 alkyl, and R^T1 represents hydrogen or C_1-6 alkyl; and where group of substutuents C consists of hydroxyl, C_1-6 alkyl, 3-10-member non-aromatic heterocyclic group and di-C_1-6 alkylaminogroup, to pharmaceutical composition possessing anti-tumor activity, to inhibitors of: hepatocyte growth factor receptor, angiogenesis and cancer dissemination, as well as to anti-tumor medication.

EFFECT: obtaining novel compounds which demonstrate anti-tumor activity.

31 cl, 111 ex, 18 tbl