PHOTOSTABLE PHARMACEUTICAL COMPOSITION FOR THE THERAPY OF FOCI OF BACTERIAL DISEASE Russian patent published in 2018 - IPC A61K31/409 A61K47/40 A61P31/02 

FIELD: medicine.

SUBSTANCE: present invention relates to medicine, namely to pharmaceutical composition and a process for its preparation. Claimed pharmaceutical composition is prepared by mixing Twin-80 and water to obtain an aqueous solution of Twin-80, simultaneous dissolution of hydroxypropyl-beta-cyclodextrin and methyl ester 13³-N-(N-methylnicotinil) bacteriopurpurinimide with uniform stirring and heating to temperature of 60 °C to give an aqueous solution of Twin-80, hydroxypropyl-beta-cyclodextrin and methyl ester 13³-N-(N-methylnicotinil) bacteriopurpurinimide, filtering the aqueous solution of Twin-80, hydroxypropyl-beta-cyclodextrin and methyl ester 13³-N-(N-methylnicotinyl) bacteriopurpurinimide to obtain an aqueous solution of the claimed pharmaceutical composition, drying the aqueous solution of the claimed pharmaceutical composition to obtain the claimed pharmaceutical composition. Resulting composition has the following composition, wt.%: methyl ester 13³-N-(N-methylnicotinyl) bacteriopurpurinimide 1.0÷2.0; hydroxypropyl-beta-cyclodextrin 94÷96; Twin-80 3.0÷4.0.

EFFECT: claimed pharmaceutical composition exhibits a high level of photostability, as well as a high level of efficacy of therapy for foci of bacterial damage and is used to prepare dosage forms for parenteral administration.

3 cl, 4 ex, 9 tbl