FIELD: biotechnology; biochemistry.
SUBSTANCE: group of inventions relates to biotechnology, biochemistry, molecular biology, microbiology. Disclosed is a modified endolysin polypeptide having the amino acid sequence SEQ ID NO: 1, having antimicrobial activity with respect to Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli. There are also created an antibacterial composition, a drug and a method for treating diseases caused by bacteria Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, using modified endolysin polypeptide.
EFFECT: group of inventions provides the creation of an effective agent having bactericidal action on gram-negative bacteria of the species Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli, including those having multiple antibiotic resistance.
11 cl, 6 dwg, 1 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730614C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST GRAM-NEGATIVE BACTERIA: PSEUDOMONAS AERUGINOSA, ACINETOBACTER BAUMANNII, KLEBSIELLA PNEUMONIAE AND SALMONELLA TYPHI (EMBODIMENTS) | 2019 |
|
RU2730615C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730613C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS AN ANTIMICROBIAL AGENT DIRECTED AGAINST ACINETOBACTER BAUMANNII BACTERIA, (EMBODIMENTS) | 2019 |
|
RU2730616C1 |
| BACTERICIDAL PHARMACEUTICAL COMPOSITION FOR PARENTERAL USE IN THE FORM OF LYOPHILIZATE WITH ENDOLYSIN | 2021 |
|
RU2792679C1 |
| BACTERICIDAL PHARMACEUTICAL COMPOSITION FOR TOPICAL APPLICATION IN THE FORM OF AN ENDOLYSIN-CONTAINING BACTERICIDAL GEL | 2021 |
|
RU2781050C1 |
| BACTERIOPHAGES, PHAGE PEPTIDES AND METHODS FOR APPLICATION THEREOF | 2011 |
|
RU2614114C2 |
| LYSINE POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | 2016 |
|
RU2724545C2 |
| BETA-HAIRPIN PEPTIDE WITH ANTIMICROBIAL ACTIVITY AGAINST MULTIDRUG-RESISTANT BACTERIA | 2023 |
|
RU2812977C1 |
| ANTIBACTERIAL COMPOSITION FOR PREVENTION OR TREATMENT OF HOSPITAL INFECTIONS (VERSIONS), BACTERIOPHAGE STAMPS USED TO OBTAIN SUCH COMPOSITION | 2015 |
|
RU2628312C2 |
