METHOD FOR PHOTODYNAMIC INACTIVATION OF GRAM-NEGATIVE PATHOGENIC MICROORGANISMS Russian patent published in 2022 - IPC A61K31/409 A61P31/04 A61N5/67 

FIELD: microbiology.

SUBSTANCE: invention relates to microbiology and medicine and is intended for photodynamic inactivation of gram-negative pathogenic microorganisms in vivo, including antibiotic-resistant nosocomial microflora, using a photosensitizer, which is a mono-cationic derivative of chloride e₆, the formula indicated below, consisting in introduction into the focus of inflammation of a composition with a photosensitizer concentration of 0.0035 mol/kg containing, wt.%: 1 nonionic surfactant Twin 80 as a carrier, 0.1 disodium salt of ethylenediaminetetraacetic acid (Na₂H₂Edta), 10 glycerin, 2 dimethyl sulfoxide and 1 sodium alginate, and irradiation with red light with a wavelength of λ=660 nm and a light energy density of 80 J/cm².

EFFECT: destruction of pathogenic gram-negative microorganisms, including antibiotic-resistant nosocomial microflora in vivo, by carrying out their photodynamic inactivation.

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