NOVEL 4-METHEXIPIROLS DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREOF Russian patent published in 2018 - IPC C07D207/48 A61K31/40 A61P1/04 A61P9/12 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a 4-methoxypyrrole derivative of formula I, wherein R₁, R₂ and R₃ each independently is hydrogen or halogen, with the proviso that R₁, R₂ and R₃ they can not be hydrogen simultaneously, and R₄ and R₅ each independently is hydrogen, halogen, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl or C_1-4 haloalkoxy, with the proviso that R₄ and R₅ can not be hydrogen simultaneously, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions containing it. formula 1.

EFFECT: as a result, 4-methoxypyrrole derivatives or pharmaceutically acceptable salts thereof in accordance with the invention can be effectively used for preventing and treating gastrointestinal tract injuries caused by ulcers of the digestive tract, gastritis, reflux esophagitis or Helicobacter pylori; also 4-methoxypyrrole derivatives or pharmaceutically acceptable salts thereof have an inhibitory action against GPCR and therefore can be effectively used for preventing and treating diseases mediated by 5-HT receptor or mediated by muscarinic acetylcholine receptor.

16 cl, 9 tbl, 33 ex