ANTIBODY-DRUG CONJUGATE Russian patent published in 2018 - IPC C07K16/28 

FIELD: biochemistry.

SUBSTANCE: described is a group of inventions comprising an antibody-drug conjugate for the treatment of a tumour and/or cancer, a drug, an antitumour drug and/or an anticancer drug containing said antibody-drug conjugate, a pharmaceutical composition, a method of treating a tumour and/or cancer, a drug-linker intermediate, a linker for preparing said antibody-drug conjugate. Antibody-drug conjugate comprises an antitumour compound conjugated with the antibody via a linker having a structure represented by the following formula: -L¹-L²-L^P-NH-(CH₂)n¹-L^a-L^b-L^c-, where the antibody is attached to the terminal of L¹, and the antitumour compound is attached to the terminal of L^c with the nitrogen atom of the amino group at position 1 as the binding site.

EFFECT: proposed invention widens the range of agents with antitumour activity.

53 cl, 22 dwg, 75 ex