ANTI-HER3 ANTIBODY-DRUG CONJUGATE Russian patent published in 2020 - IPC A61K47/64 A61K39/395 A61K31/535 C07K16/28 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly to antibody-drug conjugates for treating a tumour and/or cancer, as well as to a pharmaceutical composition and a method of treating a tumour and/or cancer. Disclosed is an antibody-drug conjugate, which is

conjugated with an anti-HER3 antibody in the form of a drug-linker structure. Also disclosed is an antibody-drug conjugate for treating a tumour and/or cancer presented by the following formula

where n is average number of conjugated units of drug-linker structure conjugated with anti-HER3 antibody, and where the anti-HER3 antibody includes the amino acid sequences presented by SEQ ID No: 583 and 584 of heavy and light chains, respectively. Also disclosed are pharmaceutical compositions containing said antibody-drug conjugates, and methods of treating the tumour using said antibody-drug conjugates.

EFFECT: group of inventions widens the range of antitumour agents.

23 cl, 30 dwg, 1 tbl, 23 ex