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(19)

(11)

2 705 367

(13)

(51)

IPC

A61K31/4745(2006-01-01)

C07K16/28(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

C07D221/20(2006-01-01)

(21) (22)

Application

2016130095, 2014-12-24

(24)

Start date

2014-12-24

(22)

Actual filing date

2014-12-24

(45)

Published

2019-11-07

(72)

Inventor

Agatsuma TosinoriTakakhasi SuKhasegava DzunOkadzima DaisukeKhamada KhirofumiYamaguti Miki

(73)

Holder

Dajiti Sankio Kompani, LimitedSapporo Medikal Yuniversiti

ANTI-TROP2 ANTIBODY-DRUG CONJUGATE Russian patent published in 2019 - IPC A61K31/4745 C07K16/28 A61K39/395 A61P35/00 C07D221/20

Abstract RU 2705367 C2

FIELD: medicine.

SUBSTANCE: invention relates to an antibody-drug conjugate, wherein the antitumour compound represented by the formula:

is conjugated to the anti-TROP2 antibody through a thioether bond, which is formed on the disulphide bond section present in the hinge portion of the anti-TROP2 antibody, through a linker having a structure represented by -L¹-L²-L^P-NH-(CH₂)n¹-L^a-(CH₂)n²-C(=O)-.

EFFECT: technical result is obtaining a novel conjugate for providing an antitumour drug exhibiting an excellent therapeutic effect, which is excellent in terms of antitumour effect and safety.

28 cl, 22 ex, 2 tbl, 27 dwg

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RU 2 705 367 C2

Authors

Agatsuma Tosinori

Takakhasi Su

Khasegava Dzun

Okadzima Daisuke

Khamada Khirofumi

Yamaguti Miki

Dates

2019-11-07—Published

2014-12-24—Filed