METHOD FOR ISOLATING SPATIAL ISOMERS OF N, N'-DIMETHYLGLYCOLURIL Russian patent published in 2018 - IPC C07D487/04 C07D487/08 C07D247/00 

Abstract RU 2665714 C1

FIELD: technological processes.

SUBSTANCE: invention relates to a method for isolating spatial isomers of N,N'-dimethylglycoluril, namely 2,6-dimethylglycoluryl and 2,8-dimethylglycoluril, comprising the preparative separation of a reaction mixture obtained by reacting two portions of N-methyl urea and one portion of glyoxal, by liquid chromatography, characterized by use of water-acetonitrile mixture as a stationary phase of octadecylsilyl silica gel and eluents of the following composition, wt. %: acetonitrile 2–8, water 92–8.

EFFECT: technical result is the production of high purity reagents, which are used for fine organic synthesis.

1 cl, 2 ex, 1 dwg

Similar patents RU2665714C1

Title Year Author Number
METHOD OF PURIFYING GLYCOLURIL FROM HYDANTOIN IMPURITY 2019
  • Kurgachev Dmitrij Andreevich
  • Bakibaev Abdigali Abdimanapovich
  • Novikov Dmitrij Vladimirovich
RU2708590C1
METHOD OF PRODUCING N-NITROSO-N2-CHLOROETHYL)CARBAMOYL]-L-ORNITHINE 2015
  • Krasnov Viktor Pavlovich
  • Levit Galina Lvovna
  • Musijak Vera Vasilevna
  • Matveeva Tatjana Viktorovna
  • Tumashov Andrej Arturovich
  • Shprakh Zoja Sergeevna
  • Charushin Valerij Nikolaevich
RU2601753C1
METHOD OF PRODUCING SEPARATE N -NITROSO- N -[(2-CHLOROETHYL) CARBAMOYL]-L-LYSINE AND N -[(2-CHLOROETHYL)-N-NITROSOCARBAMOYL]-L-LYSINE 2008
  • Grishakov Aleksandr Nikolaevich
  • Krasnov Viktor Pavlovich
  • Levit Galina L'Vovna
  • Beljavskij Aleksandr Vladimirovich
  • Matveeva Tat'Jana Viktorovna
  • Tumashov Andrej Arturovich
RU2408576C2
PROCESS FOR PRODUCING DERIVATIVES OF (ERGOLINYL)-N,N-DIETHYLUREA OR THEIR SALTS 0
  • Rajnkhard Khorovski
  • Volfgang Ker
  • Gerkhard Zauer
  • Ulrikh Eder
  • Khans Peter Lorents
SU965356A3
METHOD OF PREPARING GLYOXAL ETHYLALKYLMONOTHIOACETALS 0
  • Shekhtman Roman Isaakovich
  • Rybakova Irina Alekseevna
  • Prilezhaeva Elena Nikolaevna
SU721422A1
METHOD FOR PREPARING N-SUBSTITUTED LACTAMS 2003
  • Khardina I.A.
  • Alejnikova T.P.
  • Tuzhikov O.I.
  • Kovalets I.Ju.
  • Derbisher V.E.
  • Popov A.N.
RU2246487C9
PYRROLIDIN-3-YLACETIC ACID DERIVATIVE 2012
  • Josida Itiro
  • Okabe Tadasi
  • Matsumoto Yasunobu
  • Vatanabe Nobukhisa
  • Okhasi Josiaki
  • Onizava Yudzi
  • Kharada Khitosi
RU2615135C2
METHOD OF SYNTHESIS OF CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2-(Z)-METHOXYIMINOACETAMIDO]-3- [(-1-METHYL-1- PYRROLIDINIO) -METHYL]- CEPH-3-EM -4-CARBOXYLATE MONO- OR DIHYDRATE DIHYDROCHLORIDE ESSENTIALLY FREE FROM ANTIISOMER AND Δ-ISOMER 1992
  • Gari M.F.Lim[Ca]
  • Dzhon M.Raubaj[Us]
  • Ehlizabet Ehnn Gehrofalo[Us]
RU2042681C1
SORBENT FOR OPTIC ISOMER CHROMATOGRAPHY AND METHOD OF ITS OBTAINMENT 2006
  • Staroverov Sergej Mikhajlovich
  • Kuznetsov Mikhail Aleksandrovich
  • Sakharov Ivan Jur'Evich
  • Jaropolov Aleksandr Ivanovich
  • Morozova Ol'Ga Vladimirovna
  • Shumakovich Galina Petrovna
RU2348455C2
N-NITROSO-N-[(2-CHLOROETHYL)CARBAMOYL]-L- ORNITHINE 2012
  • Krasnov Viktor Pavlovich
  • Levit Galina L'Vovna
  • Matveeva Tat'Jana Viktorovna
  • Baryshnikov Anatolij Jur'Evich
  • Baryshnikova Marija Anatol'Evna
  • Saprykina Nina Semenovna
  • Charushin Valerij Nikolaevich
RU2503657C1

RU 2 665 714 C1

Authors

Kurgachev Dmitrij Andreevich

Bakibaev Abdigali Abdimanapovich

Malkov Viktor Sergeevich

Dates

2018-09-04Published

2017-12-28Filed