FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (1)
,
where R is a C1-6alkyl group, unsubstituted or containing 1–3 substitutes, selected from a group of substitutes A, C3-8cycloalkyl group, unsubstituted or containing 1–3 substitutes, selected from group of substitutes A, or C3-8cycloalkenyl group, unsubstituted or containing 1–3 substitutes, selected from a group of substitutes A, X denotes C1-6alkyl group, Y and Z are identical or differ from each other, and each of them is a halogen atom or C1-6alkyl group, unsubstituted or containing 1–3 substitutes, selected from a group of substitutes B, n equals 0 or 1, group of substitutes A consists of halogen atoms, and group of substitutes B consists of halogen atoms, having inhibitory effect on fractalkine-CX3CR1 pathway.
EFFECT: disclosed is a pyrrolidin-3-yl acetic acid derivative.
20 cl, 4 dwg, 5 tbl, 14 ex
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