COMPOSITIONS OF CARBOHYDRATE VACCINE FOR INDUCING IMMUNE RESPONSES AND USES THEREOF IN CANCER TREATMENT Russian patent published in 2018 - IPC A61K47/42 C07K7/06 

Abstract RU 2666141 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound used in medicine, said compound having the formula

,

where n – an integer from 1 to 1,500, m is an integer from 1 to 10, each of the units Globo H (Fucα1→2 Galβ1→3 GalNAcβ 1→3 Galα1→4 Galβ1→4 Glc) covalently bonded to the keyhole limpet hemocyanin (KLH) subunit through residues of basic amino acids selected from arginine, lysine, histidine, and combinations thereof, through the depicted linker, wherein the ratio of epitopes to carrier molecules is in the range of 750 to 3,000.

EFFECT: new compounds have been proposed, as well as pharmaceutical compositions based on said compounds, which are effective in the treatment of cancer and the production of monoclonal antibodies for therapeutic or diagnostic purposes.

45 cl, 5 tbl, 8 ex, 33 dwg

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RU 2 666 141 C2

Authors

Yuj Chen-Der Toni

Van Chen-Chi Iren

Li Vej-Khan

Lin Yuj-Chen

Lin Yuj-Khsin Tom

Chen I-Tszyuj

Dates

2018-09-06Published

2014-09-15Filed