METHOD FOR PREDICTING I-III STAGES OF ACTIVE RETINOPATHY OF RETINOPATHY OF PREMATURITY ON THE BASIS OF DATA OF FLUORESCENCE ANGIOGRAPHY Russian patent published in 2018 - IPC A61B3/12 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to ophthalmology, and can be used to predict the course of I–III stages of active retinopathy of prematurity (hereinafter RP) based on fluorescent angiography. Fluorescent-angiographic examination of the retina is carried out. When active RP signs of delay in the formation of vessels characterized by vascular breakdown at the border of the vascularized and avascular retina are revealed at stage I, as well as multiple collateral vessels without liqueur signs in the same zone, a favorable type of flow with regression of stage I RP is predicted. If the active RP is revealed at stage I of an extensive, non-perfused zone of the avascular retina along the border of the non-perfused retina in the vascularized zone of multiple small vessels in the form of beams without signs of a liqueur, an unfavorable type of the course of stage I RP is predicted with progression to stage II. If the active RP is revealed at stage II of the correct course of the vessels in the zone of the vascularized retina of convoluted collateral vessels before the demarcation shaft, which are visualized already in the early arteriovenous phase, and the detection of the microvasculature, predict a favorable type of flow with regression of stage II RP. When the active RP is revealed at stage II of an extensive non-perfused zone of the retina of different degree and extent of hyperfluorescence in the region of the demarcation shaft appearing in the arteriovenous phase, shunting both within the same vascular arcade and between adjacent arcades, multiple small, hyperfluorescent wings of a rounded shape with distinct boundaries located near the border with the avascular retina and in the posterior pole, as well as areas of capillary non-perfusion before the demarcation shaft and in the posterior pole predict an unfavorable type of flow of stage II RP with progression to stage III. If the active RP is revealed at the stage III of a small peripheral non-perfused zone localized mainly in the temporal segment, in zones of extraretinal proliferation of areas of hyperfluorescence with length of 1–4 hour meridians with a slight extravasal yield, a favorable flow type with regression of stage III RP is predicted. If the active RP is revealed at stage III of an extensive non-perfusion zone on the border with the avascular retina with obvious absence of capillaries and shunts, different degrees of hyperfluorescence on the border of the vascularized retina in the zones of extraretinal proliferation, multiple small hyperfluorescent patches with distinct boundaries, located predominantly near the avascular retina in the zones of retinal non-perfusion, an unfavorable type of flow of stage III PH with progression to stage IV is predicted.

EFFECT: method provides a reliable prognosis of the active stages of retinopathy of prematurity through the detection of pathological phenomena of fluorescence in absence of ophthalmoscopic signs or an unclear ophthalmoscopic picture.

1 cl, 6 dwg