QUINOLINE OR QUINAZOLINE DERIVATIVE USED AS AXL INHIBITOR Russian patent published in 2018 - IPC C07D215/54 C07D401/12 C07D401/14 A61K31/4709 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely a novel heterocyclic compound of formula (I) or a salt thereof, where R¹ is (1) a C1-6 alkyl group optionally substituted with 1-2 R¹¹, (2) a C3-6 carbon ring selected from phenyl, cyclopropyl, cyclobutyl and cyclohexyl optionally substituted with 1-2 R¹² or (3) a 4 to 6 membered heterocycle selected from oxetane, tetrahydropyran, pyrazole and pyridine optionally substituted with 1 R¹³, R² is (1) C1-4 alkyl group, (4) oxo group, (5) -OR²¹ group or (6) =NR²² group, R³ is (1) C1-4 alkyl group, (2) a halogen atom, R⁴ is (1) C1-4 an alkoxy group, (2) C1-4 haloalkyl group, (3) -OR⁴¹ group, R⁵ is (1) hydrogen atom, (2) C1-4 alkyl group, R¹¹ is (1) -OR¹⁰¹ group, (2) SO₂R¹⁰² group, (3) NR¹⁰³R¹⁰⁴ group or (4) C3-6 carbon group selected from phenyl, cyclopropyl, cyclohexyl optionally substituted with 1 halogen atom, R¹² is (1) C1-4 alkyl group, optionally substituted by hydroxyl group or (2) a halogen atom, R¹³ is (1) C1-4 alkyl group, optionally substituted by hydroxyl group, R²¹ is hydrogen atom, R²² is (1) by hydroxyl group or (2) C1-4 an alkoxy group, R⁴¹ is (1) hydrogen atom; (2) C1-5 alkyl group, substituted with 1 to 2 substituents selected from (a) 5-6 membered cyclic group selected from pyrrolidine, piperidine, piperazine, morpholine, dioxolane and phenyl, optionally substituted with 1 to 2 substituents selected from (i) a C1-4 alkyl group and (iii) halogen atom, (b) NR⁴⁰¹R⁴⁰², (c) hydroxyl group and (d) SO₂R⁴⁰³ group; R¹⁰¹ and R¹⁰² are (1) a hydrogen atom or (2) C1-4 alkyl group, R¹⁰³, R¹⁰⁴, R⁴⁰¹, R⁴⁰² and R⁴⁰³ - each, independently, represents (2) C1-4 alkyl group, A is (1) CH or (2) a nitrogen atom, L is (1) -O-, (2) -NH-, (3) -C(O)-, ring1 is 6-membered cyclic group selected from phenyl and pyridine, is a single bond, m = 0-4, n, p and q = 0-2, if m is two or more, the radicals R² may be the same or different, and if two R² are a C1-3 alkyl group and are on the same carbon atom, R² together with the carbon atom to which they are attached, can form a C3-4 cycloalkyl ring, if n is two, the radicals R³ may be the same or different, and if q is two, the radicals R⁴ can be the same or different. Invention also relates to a particular compound, a pharmaceutical composition based on a compound of formula (I), method of treating and/or preventing diseases associated with Axl and the use of a compound of formula (I).

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EFFECT: technical result: new heterocyclic compound used in the treatment of Axl-related diseases such as cancer, immune system diseases or circulatory system diseases is produced.

14 cl, 1 tbl, 210 ex