FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to the field of medicine and pharmaceutics, namely to pharmaceutical products for the treatment of cancer, containing a combination of 4-{4-cyano-2-[({(2'R, 4S)-6-[(2-methoxyethyl)carbamoyl]-2.3-dihydrospiro [chromene-4,1'-cyclopropan]-2'-yl}carbonyl)amino] phenyl}butanoic acid, 4-[4-cyano-2-({[(2'R,4S) -6- (isopropylcarbamoyl)-2,3-dihydrospiro [chromene-4,1'-cyclopropan]-2'-yl]carbonyl}amino)phenyl]butanoic acid, its salt or solvate with an immune checkpoint inhibitor selected from CTLA-4 and PD-1 inhibitors; as well as corresponding combinations, uses and methods of cancer treatment.
EFFECT: group of inventions provides a combination showing a strong antitumor effect.
20 cl, 5 dwg, 2 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| TRICYCLIC SPIRO COMPOUND | 2016 |
|
RU2707073C2 |
| INDOLE COMPOUND AND USE THEREOF | 2006 |
|
RU2416601C2 |
| DERIVATIVE OF PYRIMIDINE AND A FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLE, METHOD FOR PRODUCTION AND MEDICAL APPLICATIONS THEREOF | 2019 |
|
RU2775229C1 |
| BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOHUANIDINE COMPOUNDS, USEFUL FOR THE TREATMENT OF PAIN | 2013 |
|
RU2664541C2 |
| PROTEIN TYROSIN PHOSPHATASE INHIBITORS | 2020 |
|
RU2799449C2 |
| SPIRO CONDENSED DERIVATIVES OF 2,3-DIHYDROINDOLE, THEIR USE IN OPHTHALMOLOGY | 2017 |
|
RU2712039C2 |
| PHENYL DERIVATIVES | 2012 |
|
RU2619105C2 |
| CARBOXYLIC ACID COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEM, METHOD OF TREATMENT, AND APPLICATION | 2004 |
|
RU2335490C2 |
| SUBSTITUTED CHROMANS | 2015 |
|
RU2718060C2 |
| SPIRO CONDENSED PYRROLIDINE DERIVATIVES AS INHIBITORS OF DEUBIQUITINATING ENZYMES (DUB) | 2017 |
|
RU2730552C2 |
