HETEROCYCLIC COMPOUNDS, METHOD OF PREPARATION THEREOF, COMPOSITION BASED THEREON AND METHOD OF COUNTERACTION AGAINST TACHYKININ RECEPTORS Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: new heterocyclic compounds of formula I: wherein ring A and ring B are optionally substituted benzene or cycloalkane ring or optionally substituted 5- or 6-membered aromatic heterocyclic ring containing one or two heteroatoms selected from nitrogen, sulfur and oxygen. Ring C is benzene ring which is substituted by 1-3 substituents selected from halogen, halogenated C₁-C₄ alkyl, halogenated C₁-C₄ alkoxy; R is hydrogen or C₁-C₆ alkyl, one of X or Y is -NR¹, and the other is -CO-, one of these is -N=, and the other is =CR²- wherein R¹ is hydrogen, C₁-C₆ alkyl, R² is hydrogen, halogen, C₁-C₆ alkyl, carboxyl or alkoxycarboxyl group, n is 1 or 2. Compounds of formula I or salts thereof have superior antagonistic effect with respect to tachykinin receptors. Compounds of formula I are prepared by reacting corresponding carboxylic acid with compound of formula II: . Composition having activity of tachykinin receptor antagonist comprises effective amount of compound of formula I as active ingredient. Method of conateraction to techykinin receptors is carried out by adding effective amount of compound I. EFFECT: improved properties of the composition. 15 cl, 109 ex, 2 tbl