FIELD: pharmacology.
SUBSTANCE: group of inventions relates to pharmacology and medicine. Disclosed are: the use of a steroidal nitrone selected from compounds (E)-N-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H,6H,10H)-ylidene)methanamine oxide (F2) and (Z)-N-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H,6H,10H)-ylidene)methanamine oxide (F3), or pharmaceutically acceptable salts and hydrates of said compounds for the manufacture of a pharmaceutical composition or a medicament for the prevention and / or treatment of stroke or cerebral ischemia, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis; the composition based thereon, having neuroprotective action, use of said composition in combination with a thrombolytic agent for the treatment of stroke or cerebral ischemia, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.
EFFECT: technical result consists in the neuroprotective, antioxidant action of said steroidal nitrones for which the blood-brain barrier is highly permeable.
6 cl, 5 dwg, 1 tbl
