METHOD FOR INHIBITING NUCLEAR KAPPA B FACTOR WITH USING 2-ETHYL-6-METHYL-3-HYDROXIPIRIDINIUM L-2,6-DIAMINOHEXANOATE IN CULTURE OF CELLS Russian patent published in 2018 - IPC G01N33/15 A61K31/4412 G01N33/535 

Abstract RU 2669348 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology. Method is proposed for inhibiting the nuclear factor kappa B in a cell culture comprising adding a bacterial lipopolysaccharide at a concentration of 1 mcg/ml to a freshly isolated standard ficoll density gradient test for mononuclear blood cells of Wistar rats, characterized in that 2-ethyl-6-methyl-3-hydroxypyridinium L-2,6-diaminohexanoate is then added to this mixture at a final concentration of 35 mcg/ml.

EFFECT: technical result consists in the expressed inhibition of the nuclear factor kappa B in the cell culture and in the favorable safety profile.

1 cl, 1 tbl

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RU 2 669 348 C1

Authors

Danilenko Lyudmila Mikhajlovna

Pokrovskij Mikhail Vladimirovich

Kotelnikova Alla Sergeevna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Beskhmelnitsina Evgeniya Aleksandrovna

Yakushev Vladimir Ivanovich

Kostina Darya Aleksandrovna

Skachilova Sofiya Yakovlevna

Shilova Elena Vladimirovna

Burda Yurij Evgenevich

Dates

2018-10-10Published

2017-11-15Filed