FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology. The method includes modeling intracerebral hemorrhage in rats by injecting autologous blood 0.11 ml of blood/100 g of rat weight into the region of the internal capsule of the right hemisphere of the brain. To correct the pathology, 2-ethyl-6-methyl-3-hydroxy pyridinium-N-acetylaminoacetate is administered intraperitoneally at a dose of 23 mg/kg once a day for 4 days, the first time - 60 minutes before pathology modeling.
EFFECT: invention provides an effective method for correcting the neurological status in case of brain damage due to intracerebral hemorrhage.
1 cl, 2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MODELING HAEMORRHAGIC STROKE IN RATS | 2019 |
|
RU2721289C1 |
| MEDICINAL AGENT WITH ANTIHYPOXIC, ANTISTROKE, MEMORY-REFINING ACTION | 2007 |
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RU2326665C1 |
| METHOD FOR CORRECTION OF PATHOLOGY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY | 2021 |
|
RU2766785C1 |
| MEDICINAL AGENT FOR PREVENTING AND TREATING CEREBRAL DISEASES AND METHOD OF TREATING CEREBRAL DISEASES | 2015 |
|
RU2692063C2 |
| METHOD FOR CORRECTING NEUROLOGICAL DEFICIENCY OF 2-AMINO-5-ETHYL-1,3,4-THIODIAZOLIUM-N-ACETYL-AMINOETHANOATE IN TRAUMATIC BRAIN INJURY | 2021 |
|
RU2758433C1 |
| AGENT WITH ANTI-STROKE ACTION, AND METHOD FOR PREPARING IT | 2013 |
|
RU2521404C1 |
| AGENT FOR TREATMENT OF ACUTE AND CHRONIC DISTURBANCES OF CEREBRAL CIRCULATION, INCLUDING STROKE ON BASIS OF HYDROGENATED PYRIDO (4,3-b)INDOLES (VERSIONS), PHARMACOLOGICAL AGENT ON ITS BASIS AND METHOD OF ITS APPLICATION | 2006 |
|
RU2340342C2 |
| METHOD FOR PREVENTING CEREBRAL ISCHEMIA | 2018 |
|
RU2696203C1 |
| NEUROTROPIC AGENT WITH ANTIOXIDANT, ANTIHYPOXIC, NEUROPROTECTOR, ANTIAMNESIC AND ANTI-MOTION SICKNESS ACTIVITY AND CAPABLE OF ENHANCING COGNITIVE FUNCTIONS | 2008 |
|
RU2394816C1 |
| AGENT POSSESSING ANTIRADICAL, CEREBROPROTECTIVE AND ANTIISCHEMIC PROPERTIES | 2010 |
|
RU2445090C1 |
