METHOD OF CORRECTING BACTERIAL PURULENT MENINGITIS BY 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINIUM 2,6-DICHLOROPHENYL(AMINO)PHENYL ETHANOATE UNDER EXPERIMENTAL CONDITIONS Russian patent published in 2020 - IPC A61K31/545 A61K31/4425 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, neurology and infectious diseases, and can be used for treating bacterial purulent meningitis. That is ensured by simulating bacterial purulent meningitis in laboratory rats by administering into subarachnoid space 10 mcl of a suspension containing Streptococcus pneumoniae in concentration of 5*10⁹ CFU/ml, with subsequent correction of 2-ethyl-6-methyl-3-hydroxypyridinium 2,6-dichlorophenyl(amino)phenyl ethanoate in dosage of 25 mg/kg, which is introduced 7 hours after meningitis is induced intramuscularly once, and subsequent correction of ceftriaxone, initiated 18 hours after meningitis induction, in dose of 100 mg/kg/day intramuscularly once day for 7 days.

EFFECT: method provides pronounced correction of bacterial purulent meningitis, which is confirmed by low lethality, reduced degree of neurological deficiency, faster recovery of behavioral activity, low indices of oxidative stress.

1 cl, 6 tbl, 1 ex