FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely obstetrics, gynecology and pathological physiology, and can be used for early prediction of miscarriage associated with reactivation of cytomegalovirus infection. The content of interleukin 1ß (IL-1ß) in pg/ml and the concentration of nuclear factor kappa-B (NF-kb) in pg/ml are determined in serum by enzyme immunoassay in women. The level of cyclooxygenase-2 (COX-2) in ng/ml is determined in the lysate of mononuclear cells. Then the risk of developing the threat of miscarriage is predicted using the PI prognostic index calculated by the formula: PI=-280.024+(0.260×IL-1ß)-(4,271×NF-kb)+(14.031×COX-2), where PI is a prognostic index resulting from a discriminant function whose boundary value is 59.621. With PI equal to or greater than the boundary value, the threat of miscarriage associated with reactivation of cytomegalovirus infection in the early stages is predicted. When PI is less than the boundary value, it is predicted that there is no threat of miscarriage associated with reactivation of cytomegalovirus infection in the early stages.
EFFECT: method makes it possible to increase the accuracy of predicting miscarriage during early pregnancy associated with reactivation of cytomegalovirus infection by determining the content of IL-1ß, NF-kb in the blood, as well as the content of COX-2 cells in the lysate of mononuclear cells.
1 cl, 2 ex
