SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN Russian patent published in 2018 - IPC C07D277/52 C07D285/08 C07D417/12 C07D487/04 A61K31/18 A61K31/433 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I):

Formula (I) or a pharmaceutically acceptable salt thereof, where: Z is -O- or -S-; Y is - (CH₂)₃-NR₉R₁₀; R₁ is a partially unsaturated or aromatic 5- or 6-membered heterocycle; R₂ independently in each case is -F, -Cl, -Br, -CH₃ or -CN; R₃ independently in each case is -H,- F, -Cl, -Br, -CF₃, -OCF₃, -CN, (C₁-C₁₂)alkyl or (C₁-C₁₂)alkoxy; R₉ represents (C₁-C₆)alkyl, (C₃-C₈)cycloalkyl, pyrazolyl or pyridinyl; here R₉ optionally is further substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR₁₁, -CONR₁₁R₁₂, -SO₂R₁₁, -SO₂NR₁₁R₁₂, -OH, -CN, -OR₁₁ and -NR₁₁R₁₂; where R₁₁ and R₁₂ can form a 6-membered heterocycloalkyl ring; R₁₀ is R₁₁, -COR₁₁, -COOR₁₁, -SO₂R₁₁, 5-methyl-2-oxo-1,3-dioxol-4-yl, , -COO-CH(CH₃)OCOCH(CH₃)₂; or R₉ and R₁₀ together form a piperazinone or 4-8-membered heterocycloalkyl ring, wherein said heterocycloalkyl ring is substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR₁₁, -CH₂-COOR₁₁, -OH, -NH₂, -CN and (C₁-C₈)alkoxy; R₁₁ and R₁₂ are independently H or (C₁-C₆)alkyl optionally substituted with 4-8-membered heterocycloalkyl ring; and m and n are each independently 1, 2, 3 or 4 modulating the sodium channels, in particular modulating NaV1.7.

EFFECT: modulators of the sodium channel for the treatment of pain are proposed.

40 cl, 33 ex, 2 tbl