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(19)

RU

(11)

2 669 807

(13)

C2

(51)

IPC

C07D487/04(2006-01-01)

A61K31/407(2006-01-01)

A61K47/50(2017-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2016127553, 2015-01-14

(24)

Start date

2015-01-14

(22)

Actual filing date

2015-01-14

(45)

Published

2018-10-16

(72)

Inventor

Maderna AndreasDoroski Matthew DavidChen ZechengRisley Hud LawrenceCasavant Jeffrey MichaelO'Donnell Christopher JohnPorte Alexander M.Subramanyam Chakrapani

(73)

Holder

Pfizer Inc.

BIFUNCTIONAL CYTOTOXIC AGENTS Russian patent published in 2018 - IPC C07D487/04 A61K31/407 A61K47/50 A61P35/00 

Abstract RU 2669807 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to cytotoxic dimers containing CBI and / or CPI-based subunits, antibody-drug conjugates containing such dimers and methods for using the same to treat cancer and other conditions.

EFFECT: bifunctional cytotoxic agents are prorosed.

28 cl, 9 tbl, 324 ex

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RU 2 669 807 C2

Authors

Maderna Andreas

Doroski Matthew David

Chen Zecheng

Risley Hud Lawrence

Casavant Jeffrey Michael

O'Donnell Christopher John

Porte Alexander M.

Subramanyam Chakrapani

Dates

2018-10-16—Published

2015-01-14—Filed

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