NOVEL POLYPEPTIDES Russian patent published in 2019 - IPC C07K14/435 A61K38/00 

FIELD: biotechnology; biochemistry.

SUBSTANCE: invention relates to the field of biotechnology and biochemistry, in particular to a polypeptide that binds to the neonatal Fc receptor (FcRn). Said polypeptide comprises an FcRn binding motif BM, which consists of the sequence EX₂X₃X₄AX₆X₇EIRWLPNLX₁₆X₁₇X₁₈QRX₂₁AFIX₂₅X₂₆LX₂₈X₂₉, in which X₂ is selected from A, D, E, F, H, I, K, L, N, Q, R, S, T, V, W and Y, X₃ is selected from A, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W and Y, X₄ is selected from A, D, E, F, G, H, I, K, L, N, Q, R, S, T, V, W and Y, X₆ is selected from A, G, K, Q, R, S and V, X₇ is selected from A, F, H, K, N, Q, R, S and V, X₁₆ is selected from N and T, X₁₇ is selected from F, W and Y, X₁₈ is selected from A, D, E and N, X₂₁ is selected from A, S, V and W, X₂₅ is selected from D, E, G, H, I, K, L, N, Q, R, S, T, V, W and Y, X₂₆ is selected from K and S, X₂₈ is selected from A, D, E, H, K, L, N, Q, R, S, T, W and Y, and X₂₉ is selected from D and R. Invention also relates to a fusion protein, a conjugate and a composition comprising said polypeptide.

EFFECT: present invention enables to obtain polypeptides that bind to FcRn.

35 cl, 10 dwg, 11 tbl, 12 ex