FIELD: medicine; biochemistry.
SUBSTANCE: invention relates to biotechnology and biochemistry, in particular to a cell penetrating peptide. Said peptide consists of an amino acid sequence of SEQ ID NO: 1 and is capable of mediating intracellular delivery of a botulinum light chain. Invention also relates to a conjugate for intracellular delivery of a botulinum toxin light chain. In said conjugate, the botulinum toxin light chain is conjugated at one or both ends with an amino acid sequence of SEQ ID NO: 1. Invention also relates to a vector and to a bacterium expressing said conjugate. Present invention relates to cosmetic and pharmaceutical compositions comprising said conjugate and are intended for the treatment of dermatological diseases.
EFFECT: invention allows obtaining compositions for the treatment of dermatological diseases.
23 cl, 15 dwg, 1 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DETERMINING THE ACTIVITY OF BOTULINUM TOXIN USING CELLS | 2019 |
|
RU2803123C2 |
| PEPTIDE INHIBITED FORMATION OF SNARE COMPLEX AND ITS USE | 2021 |
|
RU2812638C1 |
| STABLE VECTOR OF CONSTITUTIVELY HIGH EXPRESSION FOR OBTAINING HPV VACCINE, AND RECOMBINANT LACTIC ACID BACTERIA TRANSFORMED BY THIS VECTOR | 2010 |
|
RU2492240C2 |
| ANTIBODY BOUND WITH CARBONIC ANHYDRASE, AND USE THEREOF | 2017 |
|
RU2727682C1 |
| METHOD FOR CANCER DETECTION | 2013 |
|
RU2646466C2 |
| NOVEL DUAL-TARGETED PROTEINS SPECIFICALLY BINDING TO DLL4 AND VEGF, AND USE THEREOF | 2014 |
|
RU2648154C2 |
| ANTIBODIES AGAINST TIGIT AND APPLICATION THEREOF | 2019 |
|
RU2750705C1 |
| FGF-R-Fc FUSED PROTEIN AND USE THEREOF | 2012 |
|
RU2560573C2 |
| FUSED PROTEIN OR PEPTIDE WITH INCREASED HALF LIFETIME IN VIVO, WHICH IS MAINTAINED DUE TO SLOW RELEASE IN VIVO, AND METHOD FOR INCREASING HALF LIFETIME IN VIVO USING IT | 2010 |
|
RU2503688C2 |
| ANTIBODIES TO INTERLEUKIN-6 AND USES THEREOF | 2013 |
|
RU2656162C2 |
