FIELD: biotechnology.
SUBSTANCE: vector of surface expression is proposed, which expresses constitutively the high level of antigenic protein of human papillomavirus (HPV), for obtaining HPV vaccines where the vector comprises a gene encoding the mutant protein gerE, a promoter, a complex gene of poly-gamma-glutamatesynthetase and a gene which is connected to a complex gene of poly-gamma-glutamatesynthetase and encodes an antigenic protein of human papillomavirus associated with the induction of tumor. Also, recombinant lactic acid bacteria transformed with the abovementioned vector are proposed.
EFFECT: invention can be used as a vaccine for treatment of cervical cancer.
14 cl, 11 dwg, 10 ex
| Title |
Year |
Author |
Number |
| VECTOR ENABLING SARS VIRUS ANTIGEN EXPRESSION AT CELL SURFACE, AND MICROBES TRANSFORMED BY THIS VECTOR |
2004 |
- Sung Mun Khe
- Kim Chjul Dzoong
- Dzjung Chang Min
- Khong Syng Po
- Li Dzong Sju
- Choj Dze Chjul
- Kim Kvang
- Suniti Kuroda
- Pu Kha Roung
|
RU2332457C2 |
| RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMA VIRUS EPITOPES, PROTEIN EMBEDDED ADENYLATECYCLASE OR ITS FRAGMENT, ITS THERAPEUTIC APPLICATION |
2005 |
- Preville Khav'Er-Ehdmond-Ehduard
- Leklerk Klod
- Ladant Daniel
- Timmerman Benedikt
|
RU2441022C2 |
| COMPOSITION COMPRISING LACTIC ACID BACTERIA, AN ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION AND/OR HPV-ASSOCIATED TUMORS AND AN AGENT INDUCING MUCOSAL IMMUNITY |
2016 |
- Kawana, Kei
- Igimi, Shizunobu
|
RU2728788C2 |
| APPLICATION OF S-LAYER PROTEIN DOMAIN FROM LACTOBACILLUS BREVIS AS COMPONENT OF SYSTEM FOR FILM PROTEINS EXPOSURE ON LACTIC ACID BACTERIA CELLS SURFACE |
2016 |
- Rykov Sergej Viktorovich
- Berezina Oksana Valentinovna
- Shashkina Olesya Leonidovna
|
RU2639246C1 |
| RECOMBINANT PROTEIN COMPOSITION, METHOD FOR PREPARING SUCH COMPOSITION, PHARMACEUTICAL KIT OF REAGENTS FOR IMMUNOTHERAPY AND PROPHYLACTIC VACCINATION OF TUMOR DISEASES IN ANUS-GENITAL SPHERE, METHOD FOR IMMUNOTHERAPY AND PROPHYLACTIC VACCINATION BASED ON THEREOF |
2002 |
- Pal'Tsev M.A.
- Severin E.S.
- Kiselev O.I.
- Kiselev V.I.
- Sveshnikov P.G.
|
RU2229307C1 |
| IMMUNOGENIC COMPOSITION BASED ON RECOMBINANT PROTEINS E6-CBD AND E7-CBD FOR THE TREATMENT OF MALIGNANT NEOPLASMS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS TYPE 16 |
2023 |
- Yudin Sergej Mikhajlovich
- Keskinov Anton Arturovich
- Subbotina Marina Evgenevna
- Gromov Aleksandr Viktorovich
- Lyashchuk Aleksandr Mikhajlovich
- Grunina Tatyana Mikhajlovna
- Sergienko Olga Vasilevna
- Karyagina-Zhulina Anna Stanislavovna
- Lunin Vladimir Glebovich
|
RU2805482C1 |
| METHOD TO PRODUCE PROTEIN E7-HSP70 AND YEAST STRAIN Saccharomyces cerevisiae FOR ITS REALISATION |
2012 |
- Kozlov Dmitrij Georgievich
- Cheperegin Sergej Ehduardovich
- Gubajdullin Irek Il'Jasovich
- Efremov Boris Dmitrievich
- Tjurin Oleg Vladimirovich
- Zalunin Igor' Arsen'Evich
|
RU2489481C1 |
| CyaA-CARRIED POLYPEPTIDE (VERSIONS) AND USE TO INDUCE BOTH THERAPEUTIC AND PROPHYLACTIC IMMUNE RESPONSES |
2012 |
- Eskerr Mishel
- Momo Mari
- Guber Ann
- Misseri Jolanda
|
RU2668795C2 |
| RECOMBINANT FUSED PROTEIN, PREPARATION FOR IMMUNOTHERAPY BASED ON THEREOF AND METHOD FOR IMMUNOTHERAPY OF RELAPSING LARYNX PAPILLOMATOSIS |
2005 |
- Sveshnikov Petr Georgievich
- Kiselev Vsevolod Ivanovich
- Jarotskij Sergej Viktorovich
- Mogutov Mikhail Aleksandrovich
|
RU2290204C1 |
| MUCOSAL VACCINE FOR IMMUNE THERAPY OF DISEASES CAUSED BY HUMAN PAPILLOMA VIRUSES, AND RELATED THERAPY (VERSIONS) |
2008 |
- Kiselev Vsevolod Ivanovich
- Sveshnikov Petr Georgievich
- Pal'Tsev Mikhail Aleksandrovich
|
RU2377305C1 |
