FIELD: medicine.
SUBSTANCE: invention relates to medicine, specifically, oncology, and can be used to treat neoplasia in a subject. To this end, an antibody that binds human colony stimulating factor 1 receptor (CSF1R) is administered to a subject with neoplasia. Antibody blocks binding of colony stimulating factor 1 (CSF1) to CSF1R at such a dose that the amount of CD16+ monocytes decreases by at least 30 %.
EFFECT: invention provides treatment for neoplasia in a subject.
8 cl, 15 dwg, 14 ex, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS OF TREATING PATHOLOGICAL CONDITIONS WITH ANTIBODIES WHICH BIND TO THE COLONY-STIMULATING FACTOR 1 RECEPTOR (CSF1R) | 2013 |
|
RU2718751C2 |
| METHOD AND COMPOSITION FOR REDUCTION OF MICROMOLECULE AGGREGATION UNDER PHYSIOLOGICAL CONDITIONS | 2009 |
|
RU2563823C2 |
| METHODS AND COMPOSITIONS FOR DIAGNOSTICS OF ANKYLOSING SPONDYLITIS WITH APPLICATION OF BIO-MARKERS | 2006 |
|
RU2438704C2 |
| MONOCLONAL ANTIBODIES AND METHODS OF USING THEM | 2017 |
|
RU2694412C2 |
| HUMAN INTERLEUKIN 17 (IL-17) ANTIBODIES AND USING THEM | 2009 |
|
RU2539029C2 |
| PROTEINS BINDING PROSTAGLANDIN E2 AND USING THEM | 2009 |
|
RU2559525C2 |
| ANTI HUMAN INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (IL1RAP) ANTIBODIES AND USES THEREOF | 2015 |
|
RU2710787C2 |
| IL-17A LINKING AGENT AND METHODS FOR USE THEREOF | 2014 |
|
RU2682046C1 |
| METHODS OF TREATING PSORIASIS | 2008 |
|
RU2475265C2 |
| METHODS FOR TREATMENT USING ANTI-IL-17A ANTIBODIES | 2016 |
|
RU2754683C2 |
