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(19)

(11)

2 539 029

(13)

(51)

IPC

C07K16/24(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2011116927/10, 2009-09-21

(24)

Start date

2009-09-21

(22)

Actual filing date

2009-09-21

(45)

Published

2015-01-10

(72)

Inventor

Iogannes AuerNikolaa DimoudisGi ZhorzhPetra KhankeKhendrik KnetgenKlehr Luiz LangrishEhkkekhard Messner

(73)

Holder

Roshe Glikart Ag

HUMAN INTERLEUKIN 17 (IL-17) ANTIBODIES AND USING THEM Russian patent published in 2015 - IPC C07K16/24 C12N15/13 C12N15/63 A61K39/395 A61P37/00

Abstract RU 2539029 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to immunology. There are presented: an antibody binding to interleukin-17 (IL-17) characterised by 6 CDR of a light and heavy chain, as well as a coding nucleic acid and a vector for expression of the above antibody. What is described is a pharmaceutical composition for treating a patient with multiple sclerosis, rheumatoid arthritis, psoriasis, Crohn's disease, chronic obstructive pulmonary disease, asthma, graft rejection on the basis of the above antibody. What is disclosed is a method for preparing the antibody by means of expressing the respective nucleic acid and recovering the antibody from a cell culture or a cell culture supernatant.

EFFECT: using this invention provides the antibody with IC₅₀twice as much as shown by in vitro IL-6 and IL-8 neutralisation as compared to the known NVP-AIN-497 antibody, which binds human IL-17A and IL-17F that can find application in medicine in therapy of various inflammatory diseases.

9 cl, 6 tbl, 11 ex

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RU 2 539 029 C2

Authors

Iogannes Auer

Nikolaa Dimoudis

Gi Zhorzh

Petra Khanke

Khendrik Knetgen

Klehr Luiz Langrish

Ehkkekhard Messner

Dates

2015-01-10—Published

2009-09-21—Filed