METHOD OF OBTAINING 6-METHYL-2-ETHYLPYRIDINE-3-OL SALT OF (2S)-2-ACETAMINOPENTANEDIOIC ACID Russian patent published in 2018 - IPC C07D213/65 

Abstract RU 2671200 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method for producing 6-methyl-2-ethylpyridin-3-ol salts of (2S)-2-acetaminopentanedioic acid, which involves carrying out a salt formation reaction between N-acetyl-L-glutamic acid and 2-ethyl-6-methyl-3-oxypyridine in the presence of a solvent and subsequent crystallization, where the solvent is an azeotropic mixture of isopropyl alcohol and water, and the crystallization is carried out in acetone.

EFFECT: technical result is achieved by the fact that a new method of obtaining 6-methyl-2-ethylpyridin-3-ol salt of (2S)-2-acetaminopentanedioic acid has been developed, which allows to increase the yield of the product, which, in turn, can be used as the active substance of drugs.

6 cl, 2 ex

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Authors

Dates

2018-10-30Published

2015-12-07Filed