METHOD OF COMBINED MEDICINAL TREATMENT OF PATIENTS WITH ESSENTIAL UNRESECTABLE REGIONAL SQUAMOUS IB2-IIIB CERVICAL CANCER Russian patent published in 2018 - IPC A61K31/145 A61K31/337 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, oncology, and can be used to treat cervical cancer (CC). In the preoperative period, two courses of regional chemotherapy are carried out with an interval of 3 weeks according to the following scheme: a) on the first day before and after the intra-arterial administration of cisplatin, hyperhydration is performed according to the scheme: 2.0 L 0.9 % NaCl supplemented with 20 mM KCl, solution of sodium chloride 400 ml of 0.9 % or 5 % dextrose, furosemide 40 mg (2.0), antiemetics, then intra-arterially administered cisplatin at a dose of 75 mg/m² on 400 ml of physiological solution, the administration of cisplatin is performed alternately in the right and left uterine arteries by 200.0 ml of the prepared solution at a rate of 3–4 ml/min; b) the next day, premedication is performed according to the following scheme: 12 and 6 hours before the administration of paclitaxel, 20 mg of dexamethasone is administered intramuscularly, 30–60 minutes before the administration of paclitaxel, 50 mg of diphenhydramine, 300 mg of cimetidine or 50 mg of ranitidine are intravenously administered intravenously, paclitaxel is then given intravenously at a dose of 175 mg/m² in the form of a 3-hour infusion, diluted to a concentration of 0.3–1.2 mg/ml with a solution of 0.9 % sodium chloride or 5 % dextrose solution. Invention makes it possible to create the maximum concentration of the cytostatic directly in the tumor tissue and simultaneously realize the systemic effect of chemotherapy, as a result of which resorption of the tumor takes place and the process is translated into a resectable state.

EFFECT: effect of reducing the volume of the tumor, reducing the pain syndrome and the absence of previously available blood discharges from the genital tract is achieved.

1 cl, 4 dwg, 1 ex