METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING Russian patent published in 2018 - IPC G01N33/48 C12Q1/68 G06F19/22 

FIELD: medicine.

SUBSTANCE: proposed group of inventions relates to medicine. Methods for determining the ploidy status of a chromosome or chromosome segment in a gestating fetus are disclosed. Method comprises carrying out multiplex amplification of at least 1,000 polymorphic loci on a chromosome or a chromosome segment from a sample, which contains free-floating maternal DNA from the mother of the fetus and free-floating fetal DNA using multiple primers in one reaction to obtain a mixture of amplified fetal and maternal genomic DNA of at least 1,000 polymorphic loci.

EFFECT: proposed group of inventions provides effective non-invasive methods for the prenatal establishment of ploidy.

32 cl, 26 dwg, 4 tbl, 14 ex