FIELD: biotechnology.
SUBSTANCE: method of monitoring and detecting minimal residual disease in breast cancer, as well as a method of monitoring and detecting early recurrence or metastasis of colorectal cancer, is described. The claimed methods involve the use of high-throughput sequencing with a read depth of at least 100,000 per amplicon and the detection of two or more patient-specific single nucleotide variants above a confidence threshold of 0.97.
EFFECT: invention expands the range of diagnostic tools for breast cancer treatment.
46 cl, 100 dwg, 18 tbl, 12 ex
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